Horizon Pharma plc (Nasdaq: HZNP) agreed to buy Raptor Pharmaceutical Corp. (Nasdaq: RPTP) for about $800 million to bolster its rare-disease treatment business and expand internationally.

Pharmaceuticals have been picking up in the middle-market as companies look to replenish their pipelines. Bristol-Myers Squibb Co. (NYSE: BMY) bought Cormorant Pharmaceuticals; Pfizer Inc. (NYSE: PFE) agreed to buy Medivation Inc. (Nasdaq: MDVN); and Sunovion Pharmaceuticals Inc. is acquiring Cynapsus Therapeutics Inc. (Nasdaq: CYNA) (TSX: CTH).

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